Afsin Kaya, A.; Kaya, Elif Celenk; Sarikaya, S. Beyza Ozturk; Onaran, Abdurrahman

The new 3,4-dimethoxybenzoate complex of Cu(II) with nicotinamide was synthesized and characterized by elemental analysis, FT-IR spectroscopic study, UV-Vis spectrophotometry and mass spectrometry. The thermal behavior of the complex was studied by simultaneous TG, DTG and DTA methods in static air atmosphere. The infrared spectral characteristics of the complex is also discussed. In this complex, all ligands are coordinated to the metal ion as monodendate ligands. The final decomposition products were found to be the respective metal oxide. As it is well known, metal complexes of biologically important ligands are sometimes more effective than the free ligands. In this study the new compound was synthesized due to its functional groups such as veratric acid and nikotin amide, which have known biological characteristics and effective in terms of both enzyme and antifungal properties from recent studies. Therefore, antifulgal activity and enzyme inhibition properties of this complex have been examined.

Nas, Asiye; Kaya, Elif Celenk; Kantekin, Halit; Sökmen, Atalay; Çakir, Volkan

This work reports on a new symmetrically substituted metal-free phthalocyanine and its transition metal complexes which were prepared by a condensation of N,N'-[propan-1,3-diilbis(tiyoetan-2,1-diil)]bis(4-methylbenzenesulfonamid) (1) and 1,2-bis(2-iodomercaptoethyl)-4,5-dicyanobenzene (2) with NiCl(2), ZnCl(2), CoCl(2), CuCl(2), and PbO salts in 2-(dimethylamino) ethanol, respectively. The phthalocyanines bearing thia and aza donor atoms at the peripheral position were characterized by IR, UV-Vis, (1)H NMR, (13)C NMR, Mass spectra, and elemental analysis data. The thermal behaviors of 4-9 were investigated by TG/DTA. Novel phthalocyanines were also investigated for enlightening their possible biological activities by employing antimicrobial (antibacterial and antifungal), antineoplastic and antioxidative assays. Of all tested, four samples exhibited antimicrobial activity against test microorganisms, among which, Branhamella catarrhalis was the most sensitive one with a MIC value around 0.312 mg/mL followed by a yeast, Candida albicans (MIC. 0.625 mg/mL). Due to their colored nature, the samples were found not to be applicable for antioxidative and antineoplastic assays. (C) 2011 Elsevier B. V. All rights reserved.

Kelesoglu, Zeynep; Kaya, Elif Celenk; Kantekin, Halit; Bueyuekguengoer, Orhan

In the title compound, C31H39Br2N3O6S2, a 17-membered aza-macrocyclic ligand containing two ether O and three aza N atoms, the three pendant aromatic rings form an 'E' shape. The dihedral angles between the central benzene ring and the side ones are 17.8 (3) and 7.4 (3)degrees , and the dihedral angle between the tosyl rings is 10.6 (3)degrees . The methyl group is disordered over two orientations, with occupancies of 0.52 (15) and 0.48 (15).

Kaya, Elif Celenk; Karadeniz, Huelya; Kantekin, Halit

A tetranitrile monomer was synthesized by nucleophilic aromatic substitution of N,N'-(2,2'-(propane-1,3-diylbis(sulfanediyl))bis(ethane-2,1-diyl))bis(4-methylbenzenesulfonamide) onto 4-nitrophthalonitrile. A metal-free phthalocyanine polymer was prepared by the reaction of the tetranitrile monomer under N-2 in the presence of 2-(dimethylamino)ethanol at 145 degrees C for 24 h. Zinc(II), copper(II), cobalt(II), nickel(II), lead (II), phthalocyanine polymers were prepared by reaction of the tetranitrile with the chlorides of zinc (II), copper (II), cobalt (II), nickel (II), lead (II), employing microwave irradiation in the presence 2-(dimethylamino)ethanol at 175 degrees C, 350 W for 10 min. The thermal stabilities of the phthalocyanine compounds were determined by thermogravimetric analysis. The new compounds were characterized by a combination of IR, H-1 NMR, C-13 NMR, UV-vis, elemental analysis and MS spectral data. (C) 2009 Elsevier Ltd. All rights reserved.