Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYayıncıda açık erişim2013Fire analysis of reinforced concrete beams with 2-d plane stress concrete model
Zandi, Yousef; Burnaz, Oguz; Durmus, Ahmet
The main purpose of this study is to investigate the nonlinear response of reinforced concrete beams under standard fire conditions. With this purpose, the 2-D nonlinear structural analysis of a chosen reinforced concrete simple beam is carried out. This beam is exposed to fire form three sides and fixed distributed loads on top of it. In these structural analyses the changes of material properties of concrete and reinforcements according to increasing temperatures are taken into account. Results drawn from these analyses are compared with the results from some simplified methods and put forward some conclusions and recommendations concerning the fire design of reinforced concrete beams.
- MakaleAçık Erişim2013Evaluation of protein tyrosine phosphatase activity in patients with acute leukemia
Akdogan, Elif; Cengiz, Sevil; YIlmaz, Mustafa; Sönmez, Mehmet; Durmus, Ahmet; Oval, Ercüment; Omay, Serdar Bedii
Protein tyrosine phosphatases regulate physiological processes including growth, differentiation, metabolism and the cell cycle. Together with tyrosine kinases, they control the phosphorylation state of tyrosine residues of signaling proteins. An increased level of protein phosphorylation results in abnormal proliferation and many cancer types show a mutation or deletion of a protein tyrosine phosphatase gene. In this study we evaluated the protein tyrosine phosphatase activity in acute leukemia patients. Tyrosine phosphatase activity in bone marrow mononuclear cells of acute leukemia patients was measured using a tyrosine phosphatase assay system kit and compared with a control group. We found that tyrosine phosphatase activity in acute leukemia patients was high compared to the controls. According to subgroups of acute leukemia, tyrosine phosphatase activity in the AML-M2 subgroup was high compared to the controls. The effect of increased level of protein tyrosine phosphatase activity on leukemogenesis needs further evaluation. Studies in a large group of patients are needed to emphasize the importance of tyrosine phosphatase activity in acute leukemia patients.