Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2015On- pump koroner arter baypas greftlemede miyokarde nfarktüsü ile iskemi modifiye albüminin ilişkisi
Usta, Sefer; Doğan, Orhan Veli; Doğan, Süheyla; Demirbaş, Mine; Karahan, Süleyman Caner; Kılıç, Aşkın; Menteşe, Ümit; Aykan, Ahmet Çağrı; Turan, İbrahim; Demir, Selim
Background:­ This study aims to evaluate the potential ofischemia-modified albumin (IMA) to predict the myocardialinfarction in on pump coronary artery bypass grafting(ONCABG) patients.Methods: Fifty elective isolated ONCABG patients (41 males,9 females; mean age 66 years; range 56 to 75 years) were includedin the study. Patients were divided into perioperative myocardialinfarction (PMI; n=8) and non-infarction (NPMI; n=42) groupsaccording to perioperative cardiac troponin I (cTnI) values andECG findings. Serum IMA levels were measured preoperatively,20 minutes after aortic cross clamping, 30 minutes, at 3, 6,12 and 24 hours after declamping.Results:­ Compared to the NPMI group, the declamping 30minutes, 3, 6 and 12 hours IMA levels were higher in the PMIgroup (p=0.002, p=0.048, p=0.023, p=0.007, respectively). Inboth NPMI and PMI groups, the 20 minutes after aortic crossclamping IMA levels were higher compared to the preoperativeIMA levels (p=0.0001, p=0.038, respectively).Conclusion:­ Our study results show that IMA may be anearly marker of myocardial infarction in the ONCABGpatients.
- MakaleYalnız künye2015Evaluation of oxidative stress balance in acute deep vein thrombosis
Doğan, Orhan Veli; Doğan, Süheyla; Coşkun, Ceyhun; Menteşe, Seda Öztaş; Menteşe, Ümit; Mentese, Ahmet; Alver, Ahmet; Turan, İbrahim; Sumer, Aysegul
Bu çalışmanın amacı akut derin ven trombozlu (DVT) hastalarda toplam oksidan durum (TOS), toplam antioksidan durum (TAS) ve oksidatif stres indeksi (OSI) düzeylerini ölçerek oksidatif stres ve DVT arasındaki ilişkiyi ortaya koymak ve klinisyenlerin bu hastalarda oksidatif stresi dengelemek üzere koruyucu önlemler almasına yardımcı olmaktır.Metod: Bu çalışmada 52 DVT'li ve 45 DVT olmayan bireylerden alınan serum örneklerinde TOS, TAS ve OSI seviyeleri belirlenerek karşılaştırıldı.Bulgular: TOS ve OSI seviyeleri DVT hastalarında kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı yüksek bulunurken (p<0.0001) TAS seviyelerinde fark görülmedi, p=0.118. Hasta grubu idiopatik ve sekonder DVT olarak iki gruba ayrıldı. TOS ve OSI seviyeleri hem idiyopatik DVT hem de sekonder DVT hastalarında kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı yüksek bulundu (p<0.0001). İdiyopatik DVT hastalarında TAS seviyeleri kontrol grubundan anlamlı yüksek iken sekonder DVT hastalarında fark gözlenmedi. Sonuç: Sonuç olarak ROC eğrisine göre elde edilen spesifite ve sensitivite değerleri TOS ve OSI parametrelerinin DVT'nin tanısında kullanılabilecek birer belirteç olabileceğini göstermektedir. Aynı zamanda oksidatif stres belirteçlerinin belirlenmesi hastalarda oksidatif stresin düzeltilmesi için klinisyenlere gerekli önlemleri alabilmeleri için yol gösterici olabilir
- MakaleAçık Erişim2015Comparison of perioperative oxidative stress in endovascular and open repair of abdominal aortic aneurysm
Doğan, Orhan Veli; Menteşe, Ümit; Doğan, Süheyla; Usta, Sefer; Turan, İbrahim; Haliloğlu, Ergün; Karahan, Süleyman Caner
Background/aim: To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR).; Materials and methods: Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated.; Results: OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018). Conclusion: Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
- MakaleAçık Erişim2015Evaluation of oxidative stress balance in acute deep vein thrombosis; [Akut derin ven trombozunda oksidatif stres dengesinin değerlendirilmesi]
Menteşe, Ümit; Turan, İbrahim; Doğan, Süheyla; Sümer, Ayşegül; Coşkun, Ceyhun; Alver, Ahmet; Doğan, Orhan Veli; Menteşe, Seda Öztaş; Menteşe, Ahmet
Objective: The purpose of this study was to show the association between oxidative stress and deep venous thrombosis (DVT) by determining total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values in patients with DVT and to take precautionary measures to balance oxidative status. Methods: TOS, TAS and OSI levels in serum from 52 individuals with DVT and 45 without DVT were compared. Results: TOS and OSI levels were significantly higher in patients with DVT compared with the control group (p<0.0001), but no difference was observed in TAS levels (p=0.118). The patient group was divided into two subgroups, idiopathic and secondary DVT. TOS and OSI levels were significantly higher patients with both idiopathic DVT and secondary DVT compared to the control group (p<0.0001). TAS levels were significantly higher in patients with idiopathic DVT than in the control group, but no difference was observed in the patients with secondary DVT. Conclusion: Specificity and sensitivity values obtained from the receiver operating characteristic (ROC) curve show that TOS and OSI are both markers that can be used in the diagnosis of DVT. Also, determination of oxidative stress markers may guide clinicians to take necessary precautions to balance oxidative stress in the patients.