Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2014Is the combined use of insulin resistance indices, Including adipokines, more reliable in metabolic syndrome?
Kural, Birgül; Değer, Orhan; Erem, Cihangir; Balaban Yücesan, Fulya; Aliyazicioğlu, Rezzan; Barlak, Yaşam
Background/aim: To determine the levels of adipokines (leptin, adiponectin, resistin, and visfatin) and the indices of insulin sensitivity/ resistance, and to examine the relationship among them in patients with metabolic syndrome (MetS).; Materials and methods: The study groups included 45 subjects with MetS (31 women/14 men), and 45 sex- and age-matched non-MetS healthy volunteers (31 women/14 men). The levels of adipokines were determined by enzyme-linked immunosorbent assay.; Results: The levels of leptin and visfatin were significantly higher in the MetS than in the non-MetS subjects (P < 0.01). There was no difference in adiponectin levels in subjects with and without MetS (P = 0.052). Similarly, resistin did not show any statistically significant difference. A statistically significant positive correlation of leptin with insulin levels was observed, while negative correlations of visfatin levels with age, and resistin levels with the ratio of adiponectin to leptin, were found in the MetS (P < 0.05). The combination of adipokines, insulin resistance-sensitivity parameters, and MetS criteria parameters gave more signifcant differences than a single parameter.; Conclusion: Since the parameters mentioned above might affect, interact with, and/or interfere with each other, the combinations of these parameters might give more reliable results to evaluate the insulin resistance/sensitivity in MetS patients.
- MakaleAçık Erişim2011The relationship between the peroxisome proliferator-activated receptor gamma 2 gene polymorphism, lipids and adipokines in patients with major depression; [Majör depresyonlu hastalarda peroksizom çoǧaltici-aktive edici reseptör gama 2 gen polimorfizmi, lipidler ve adipokinlerle ilişkisi]
Aliyazicioglu, Rezzan; Deǧer, Orhan; Vanizor Kural, Birgül; Hocaoǧlu, Çiçek; Çolak, Meltem; Balaban Yücesan, Fulya
Objective: Peroxisome proliferator-activated receptor gamma (PPARγ), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPARγ gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPARγ gene, lipids and adipokines in major depression (n = 78) and control subjects (n= 64) were analyzed. Genotypes of PPARy gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPARγ gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPARγ exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression.