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- MakaleYalnız künye2026Comparison of automated subcortical segmentation methods: VolBrain vs. 3D Slicer in brain volumetry
Acer, Niyazi; Palanci, Ozgur; Ipekten, Funda; Erdogan, Furkan Mert; Yarar, Burhan; Ozyasar, Ali Faruk
Objective:Accurate volume measurements of subcortical brain structures are essential in neuroimaging studies. This study aimed to compare two automated segmentation algorithms, 3D Slicer and VolBrain, for subcortical brain volumetry. Method:Subcortical volume measurements obtained using 3D Slicer and VolBrain were compared using the Neurofeedback Skull-stripped (NFBS) dataset. Statistical analyses included the coefficient of determination (R2) and Bland-Altman (B-A) plots. Volumetric measurements from both tools were evaluated across multiple subcortical brain regions. Results:Strong agreement was observed for the caudate nucleus, thalamus, and hippocampus, while notable discrepancies were identified in the amygdala, globus pallidus, and nucleus accumbens. Both constant and proportional systematic errors were detected in certain regions, with greater variability observed in 3D Slicer measurements. Intraclass Correlation Coefficient (ICC) analysis demonstrated weak agreement for the accumbens and amygdala, and moderate agreement for the hippocampus and thalamus, highlighting region-specific differences in performance Conclusion:Both VolBrain and 3D Slicer are effective tools for subcortical brain volumetry. VolBrain provides a fully automated workflow, whereas 3D Slicer allows greater flexibility through detailed corrections. Method selection should be guided by research objectives, regions of interest, and image quality. Further validation across diverse datasets is warranted to improve clinical applicability, particularly in regions showing lower agreement.
- MakaleYalnız künye2018Volume calculation of brain structures in migraine disease by using mristudio
Palancı, Özgür; Kalaycıoğlu, Ahmet; Acer, Niyazi; Eyüpoğlu, İlker; Çakmak, Vildan A.
Migraine is a neurological disorder that is known as headache and accompanies attacks of neurological and gastrointestinal symptoms and prevents daily life activities of the person. In the literature, the volume changes of many structures in the brain have been investigated using brain magnetic resonance images (MRI) of migraine patients, but it has not yet been investigated whether there is a comprehensive and detailed volume change involving all the structures of the brain. The purpose of this study is to examine the brain structures in a wide range and to determine in which regions the volume changes. In this study, 25 healthy subjects and 25 migraine patients were included in the study. SPSS 15.0 program was used for statistical analysis. The Mristudio was used in our study when we examined the volumes of migraine patients and brain structures of healthy individuals. Statistically significant volume changes were found in the volumes of structures found in the brain frontal, parietal, occipital, temporal lobes. Volumetric changes were assessed in terms of duration of illness and frequency of attacks. In conclusion, our study is compatible with migraine pathophysiology. Structural changes in the brain are thought to be a risk factor for migraine. The evidence on the relationship of regional gray matter volumetric change detected in migraine is unclear. We believe that this ambiguity is caused by the method used.