Machine learning–enabled ECG arrhythmia classification: a systematic and educational study from signal processing to decision support

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Özet

Electrocardiogram (ECG) signals play a critical role in the early detection of cardiac arrhythmias, which remain a major cause of morbidity and mortality worldwide. While deep learning approaches have achieved high classification accuracy, their increasing complexity often limits interpretability and practical applicability. This study presents a systematic and interpretable framework for multi-class ECG arrhythmia classification, examining the effects of signal processing, feature extraction, feature selection, and evaluation strategies on classification performance. Experiments were conducted on the MIT-BIH Arrhythmia Database using two feature representations: (i) morphological and temporal features, and (ii) a compact wavelet-based representation. Sequential Forward Feature Selection (SFFS) revealed that classification performance saturates at approximately 15 features, indicating that most discriminative information is captured within a compact subset. Using this feature space, the support vector machine (SVM) achieved the best overall performance, reaching 98.54% accuracy with stable results across different configurations. The wavelet-based representation further improved performance balance, yielding lower Golden Distance (GD) values (as low as 0.0249), indicating more consistent behavior across evaluation metrics. Overall, the results demonstrate that carefully designed feature extraction and selection enable classical machine learning methods, particularly SVM, to achieve high and reliable performance, providing an interpretable alternative to more complex black-box models in ECG arrhythmia classification.

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https://doi.org/10.1038/s41598-026-56828-4Yayıncı resmi DOI adresi
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dc.contributor.authorMelek, Negin
dc.date.accessioned2026-10-22T10:21:20.358257088Z
dc.date.available2026-10-22T10:21:20.358257088Z
dc.date.issued2026
dc.description.abstractElectrocardiogram (ECG) signals play a critical role in the early detection of cardiac arrhythmias, which remain a major cause of morbidity and mortality worldwide. While deep learning approaches have achieved high classification accuracy, their increasing complexity often limits interpretability and practical applicability. This study presents a systematic and interpretable framework for multi-class ECG arrhythmia classification, examining the effects of signal processing, feature extraction, feature selection, and evaluation strategies on classification performance. Experiments were conducted on the MIT-BIH Arrhythmia Database using two feature representations: (i) morphological and temporal features, and (ii) a compact wavelet-based representation. Sequential Forward Feature Selection (SFFS) revealed that classification performance saturates at approximately 15 features, indicating that most discriminative information is captured within a compact subset. Using this feature space, the support vector machine (SVM) achieved the best overall performance, reaching 98.54% accuracy with stable results across different configurations. The wavelet-based representation further improved performance balance, yielding lower Golden Distance (GD) values (as low as 0.0249), indicating more consistent behavior across evaluation metrics. Overall, the results demonstrate that carefully designed feature extraction and selection enable classical machine learning methods, particularly SVM, to achieve high and reliable performance, providing an interpretable alternative to more complex black-box models in ECG arrhythmia classification.
dc.identifier.articlenumber26300
dc.identifier.doi10.1038/s41598-026-56828-4
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid42270808
dc.identifier.scopus2-s2.0-105047894399
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/gumushane/13425
dc.identifier.volume16
dc.identifier.wosWOS:001855413500013
dc.language.isoen
dc.publisherNature Research
dc.relation.ispartofScientific Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArrhythmia detection
dc.subjectClassical machine learning
dc.subjectECG signal processing
dc.subjectFeature engineering
dc.subjectModel evaluation
dc.subject.classificationMultidisciplinary Sciences
dc.subject.classificationScience & Technology - Other Topics
dc.subject.otherAlgorithms
dc.subject.otherArrhythmias, Cardiac
dc.subject.otherClassification Algorithms
dc.subject.otherDatabases, Factual
dc.subject.otherElectrocardiography
dc.subject.otherHumans
dc.subject.otherMachine Learning
dc.subject.otherSignal Processing, Computer-Assisted
dc.subject.otherSupport Vector Machine
dc.subject.otherWavelet Analysis
dc.subject.otheralgorithm
dc.subject.otherclassification
dc.subject.otherclassification algorithm
dc.subject.otherdiagnosis
dc.subject.otherfactual database
dc.subject.otherheart arrhythmia
dc.subject.otherhuman
dc.subject.otherprocedures
dc.subject.othersignal processing
dc.titleMachine learning–enabled ECG arrhythmia classification: a systematic and educational study from signal processing to decision support
dc.typeArticle
rdl.citation.openalex0
rdl.citation.scopus1
rdl.citation.wos0
rdl.departmentFaculty of Engineering and Natural Sciences, Gümüşhane University, Gümüşhane, 29000, Turkey
rdl.oa.statusgold
rdl.oa.urlhttps://www.nature.com/articles/s41598-026-56828-4_reference.pdf
rdl.scopus.quartileQ1
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)