Sürdürülebilir Kalkınma Amaçları
Bu dergideki yayınlar
9 →- MakaleYalnız künye2016Streptozotosin Kaynaklı Tip 1 Diyabetik Sıçanlarda Meydana Gelen Nefropatilerde Artan eNOS ve iNOS Sunumlarının Apoptozisle İlişkilendirilmesi
Dincel, Gungor Cagdas; Yildirim, Serkan
The present study was designed to evaluate the effects of high level of nitric oxide (NO) production and oxidative stress (OS) on nephropathology and to identify whether NO and OS have any correlation with apoptosis seen in diabetic kidney, elucidating the underlying mechanism(s) involved in the development of nephropathology in streptozotocin (STZ)-induced diabetic rats. Expression levels of caspase 3, caspase 9, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), 8-hydroxy-2'-deoxyguanosine (8-OHdG), for the detection of oxidative damage to DNA, were examined in diabetic kidney tissues. Results of the study revealed that the levels of 8-OHdG (P<0.005), eNOS (P<0.005), iNOS (P<0.005), caspase 3 (P<0.005) and caspase 9 (P<0.005) were remarkably higher in diabetic kidney tissues than in controls. In addition, STZ-treated animals showed significant loss of body weight and renal enlargement. It was suggested that apoptosis, OS and increased NO levels are involved in the pathogenesis of diabetic nephropathy. The results also strongly suggested that STZ-induced apoptosis through activation of the intrinsic pathway and that might be most likely related to increased NO levels. Moreover, high NO production was not only mediated by eNOS but also by iNOS. Increased NO production may contribute to hyperfiltration and microalbuminuria in early diabetic nephropathy. Furthermore, expression of 8-OHdG might give an idea of the progress and may be essential as it has a diagnostic significance for this disease. In conclusion, we believe that eNOS and iNOS overexpressions induce diabetic nephropathy by mediating apoptosis in STZ-induced rats.
- MakaleAçık Erişim2016Increased expressions of eNOS and iNOS correlate with apoptosis of diabetic nephropathy in streptozotocin-induced type 1 diabetic rats; [Streptozotosin kaynaklı tip 1 diyabetik sıçanlarda meydana gelen nefropatilerde artan eNOS ve iNOS sunumlarının apoptozisle ilişkilendirilmesi]
Dinçel, Güngör Çağdaş; Yildirim, Serkan
The present study was designed to evaluate the effects of high level of nitric oxide (NO) production and oxidative stress (OS) on nephropathology and to identify whether NO and OS have any correlation with apoptosis seen in diabetic kidney, elucidating the underlying mechanism(s) involved in the development of nephropathology in streptozotocin (STZ)-induced diabetic rats. Expression levels of caspase 3, caspase 9, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), 8-hydroxy-2′-deoxyguanosine (8-OHdG), for the detection of oxidative damage to DNA, were examined in diabetic kidney tissues. Results of the study revealed that the levels of 8-OHdG (P<0.005), eNOS (P<0.005), iNOS (P<0.005), caspase 3 (P<0.005) and caspase 9 (P<0.005) were remarkably higher in diabetic kidney tissues than in controls. In addition, STZ-treated animals showed significant loss of body weight and renal enlargement. It was suggested that apoptosis, OS and increased NO levels are involved in the pathogenesis of diabetic nephropathy. The results also strongly suggested that STZ-induced apoptosis through activation of the intrinsic pathway and that might be most likely related to increased NO levels. Moreover, high NO production was not only mediated by eNOS but also by iNOS. Increased NO production may contribute to hyperfiltration and microalbuminuria in early diabetic nephropathy. Furthermore, expression of 8-OHdG might give an idea of the progress and may be essential as it has a diagnostic significance for this disease. In conclusion, we believe that eNOS and iNOS overexpressions induce diabetic nephropathy by mediating apoptosis in STZ-induced rats.
- MakaleAçık Erişim2015Investigate the effects of non-genetic factors on calving difficulty and stillbirth rate in holstein friesian cattle using the CHAID analysis; [Genetiksel Olmayan Faktörlerin Siyah Alaca Sığırlarda Güç ve Ölü Doğuma Etkilerinin CHAID Analizi İle İncelenmesi]
Bayram, Bahri; Topal, Mehmet; Aksakal, Vecihi; Önk, Kadir
A total number of 947 calving records from 613 Holstein Friesian cows raised at a private dairy farm in Kelkit, Turkey, from 2004 to 2006 were used to study the effect of non-genetic factors on calving difficulty and stillbirth rate using CHAID algorithm. The mean calf birth weight was 41.0±0.19 kg. The overall incidence of calving difficulty and stillbirths in the Holstein Friesian herd were 9.1% and 9.4%, respectively. Calf birth weight, birth type and calving season had the greatest impact on calving difficulty. The increase in calf birth weight was associated with a significant increase in calving difficulties (P<0.01). The calving difficulty risk in twins (18.9%) was higher than in singleton calves (5.0%). The main environmental variables affecting the stillbirth rate were parity number, calf birth weight, sex of calf, calving season and calving difficulty. Parity number was statistically the most relevant factor affecting the stillbirth rate, which was also higher in primiparous (18.7%) than in multiparous cows (5.4%). As the calf birth weight increased, a significant increase was also in the stillbirth rate (P<0.01). The stillbirth rate in winter (19.7%) was higher than in other seasons (3.6%) (P<0.01). Calving assistance was associated with an increased risk of stillbirth (P<0.05). As a result, calf birth weight, birth type and calving season had the greatest impact variables on calving difficulty, however, parity, calf birth weight, sex, calving season and calving difficulty were the most effective variables on stillbirth in Holstein Friesian Cattle.
- MakaleYalnız künye2014Tereyağı stabilitesi üzerine çörekotu (Nigella sativa L.) uçucu yağı kullanılabilirliğinin araştırılması
Erdogan, Ummugulsum; Dağdemir, Elif; Cakmakci, Songul; Gündoğdu, Engin
The aim of this study was to investigate the effect of black cumin (Nigella sativa L.) essential oil on butter stability. For this aim, 0.05, 0.1 and 0.2 wt-% essential oil was added to the butter. Antioxidant activity of the essential oil was compared to that of synthetic antioxidant BHT (100 ppm). All samples were stored at 4±1oC for 90 days. Thiobarbituric acid and peroxide values of all samples containing essential oil were decreased depending on concentrations. The amount of 0.2% of essential oil had showed strong antioxidant activity, which was almost equal to that of BHT. The addition of essential oil reduced total aerobic mesophilic bacteria, lactic acid bacteria and coliform bacteria count during storage period but did not show remarkable antifungal activity. Samples containing essential oil were preferred by the panellists compared to Control sample. Present results indicate that black cumin essential oil may be considered as a new source of natural antioxidant.
- MakaleYalnız künye2014Investigation of the possible use of black cumin (Nigella sativa L.) essential oil on butter stability; [Tereyaǧi{dotless} stabilitesi üzerine çörekotu (Nigella sativa L.) uçucu yaǧi{dotless} kullani{dotless}labilirliǧinin araşti{dotless}ri{dotless}lmasi{dotless}]
Çakmakçi, Songül; Gündoǧdu, Engin; Daǧdemir, Elif; Erdoǧan, Ümmügülsüm
The aim of this study was to investigate the effect of black cumin (Nigella sativa L.) essential oil on butter stability. For this aim, 0.05, 0.1 and 0.2 wt-% essential oil was added to the butter. Antioxidant activity of the essential oil was compared to that of synthetic antioxidant BHT (100 ppm). All samples were stored at 4±1°C for 90 days. Thiobarbituric acid and peroxide values of all samples containing essential oil were decreased depending on concentrations. The amount of 0.2% of essential oil had showed strong antioxidant activity, which was almost equal to that of BHT. The addition of essential oil reduced total aerobic mesophilic bacteria, lactic acid bacteria and coliform bacteria count during storage period but did not show remarkable antifungal activity. Samples containing essential oil were preferred by the panellists compared to Control sample. Present results indicate that black cumin essential oil may be considered as a new source of natural antioxidant.
- MakaleYalnız künye2013The effects of different breeding methods on fattening performance and parameters related to slaughter, carcass and some meat quality in broiler chickens
Das, Huseyin; Aksu, Muhammet İrfan; Sabuncuoğlu, Nilüfer; Lacin, Ekrem; Coban, Omer
Bu araştırma altlıklı yer sistemi (FBG) ve kafeste (CBG) yapılan etlik piliç yetiştiriciliğinin besi performansı, kesim, karkas ve bazı karkas kalite parametrelerinin karşılaştırılması amacıyla yürütülmüştür. Hayvan materyali olarak 90 adet bir günlük Ross-308 erkek broyler civciv kullanılmıştır. FBG ve CBG gruplarında canlı ağırlık ve kümülatif canlı ağırlık değerleri arasındaki farklılığın istatistiksel olarak çok önemli (P<0.01) olduğu saptanmıştır. Deneme sonu canlı ağırlık değerleri ile ortalama canlı ağırlık artışları FBG ve CBG gruplarında sarasıyla 2530 ve 2046 g ile 2389.16 ve 1904.77 g olarak tespit edilmiştir. Deneme sonu kümülatif yemden yararlanma değerleri FBG ve CBG gruplarında sırayla 1.82 ve 1.88 olarak bulunmuş ve aralarındaki farklılığın istatistiksel olarak önemsiz (P>0.05) olduğu tespit edilmiştir. FBG ve CBG gruplarında sıcak ve soğuk karkas randımanı ile boyun, kanat, but ve kuyruk oranlarına ait değerler arasında istatistiksel olarak farklılığın olmadığı (P>0.05), göğüs oranına ait değerler bakımından ise önemli (P<0.05) farklılıkların olduğu belirlenmiştir. Göğüs etinden elde edilen L*, b* ve C* değerlerinin ve but etinden elde edilen L*, a*, b* ve C* değerleri bakımından deneme grupları arasında önemli farklılıkların olduğu (P<0.05, P<0.01) tespit edilmiştir.
- MakaleYalnız künye2013The effects of different breeding methods on fattening performance and parameters related to slaughter, carcass and some meat quality in broiler chickens; [Farklı yetiştirme metotlarının etlik piliçlerde besi performansı, kesim ve karkas özellikleri i̇le bazı et kalite parametreleri üzerine etkisi]
Lacin, Ekrem; Coban, Omer; Aksu, Muhammet Irfan; Sabuncuoglu, Nilufer; Das, Huseyin
The present study was aimed at the comparison of floor-based growth (FBG) and caged-based growth (CBG) systems in broiler production for growth performance and parameters related to slaughter, carcass and meat quality. Ninety one-day-old male Ross-308 chicks constituted the material of the study. It was determined that, in Groups FBG and CBG, the differences between body weight and cumulative body weight values were statistically very significant (P<0.01). The final body weights measured at the end of the trial and the mean body weight gain values in Groups FBG and CBG were determined as 2530 g - 2046 g and 2389.16 g - 1904.77 g, respectively. The end-trial final feed conversion rates of Groups FBG and CBG were determined as 1.82 and 1.88, respectively, and it was ascertained that the difference between the values of the two groups was statistically insignificant (P>0.05). While the hot and cold dressing percentages and the neck, wing, drumstick and tail percentages did not statistically differ between Groups FBG and CBG (P>0.05), values pertaining to breast meat displayed significant differences (P<0.05). It was determined that the L*, b* and C* values pertaining to breast meat and the L*, a*, b* and C* values pertaining to chicken drumsticks displayed statistically significant differences (P<0.05, P<0.01) between the trial groups.
- MakaleYalnız künye2012Comparison of Multiple Linear Regression and Artificial Neural Network Models Goodness of Fit to Lactation Milk Yields
Takma, Cigdem; Atil, Hulya; Aksakal, Vecihi
In this study, effects of lactation length, calving year and service period on lactation milk yield of Holstein Friesians were modeled with multiple regression and artificial neural networks (ANN) and compared goodness of fit of models. Analyses were carried on five lactations milk yields of 305 Holsteins calved at 2006, 2007 and 2008 years. After several experiments, hidden layer number was taken one and hidden nodes number were found three for the chosen architecture. Moreover, convergence criteria, maximum iteration number and epoch number were taken as 1.10(-6), 50 and 20, respectively. Adjusted coefficient of determination (R-2),root mean square error (RMSE), mean absolute deviation (MAD), mean absolute percentage error performance criteria (MAPE) were used for comparison of artificial neural network and multiple linear regression models goodness of fit. After analysis R-2 values were found among 0.62-0.85 for the five lactations with neural networks model. RMSE, MAD and MAPE criteria also were found among 480.9-1682.8, 325.2-1381.7 and 6.1-20.2, respectively. These criteria were found for R-2, RMSE, MAD and MAPE among 0.30-0.75, 1964.8-30008.7, 1576.6-2458.3 and 24.7-35.6, respectively for multiple linear regression. When the models were compared, artificial neural networks model gave better fit than multiple linear regression models. Consequently, artificial neural networks was determined an alternative method to multiple regression analysis.
- MakaleYalnız künye2012Çoklu doğrusal regresyon ve yapay sinir ağı modellerinin laktasyon süt verimlerine uyum yeteneklerinin karşılaştırılması
Takma, Çiğdem; Aksakal, Vecihi; Atil, Hulya
Bu çalışmada Siyah Alaca ineklerin laktasyon süt verimleri üzerine laktasyon süresi (LS), buzağılama yılı (BY) ve servis periyodunun (SP) etkisi çoklu regresyon ve yapay sinir ağı (YSA) ile modellenmiş ve modellerin uyum yetenekleri karşılaştırılmıştır. Analizler 2006, 2007 ve 2008 tarihlerinde buzağılayan toplam 305 adet Siyah Alaca ineğin ilk beş laktasyonuna ait süt verimleri üzerinde uygulanmıştır. Yapay sinir ağları modelinde tekrarlanan denemeler sonucunda seçilen mimariye göre, gizli katman sayısı bir ve bu katmandaki gizli düğüm sayısı üç olarak alınmıştır. Ayrıca yakınsama kriteri 1.10-6, maksimum iterasyon sayısı 50 ve algoritmanın sonlanması her bir çalıştırma için 20 devir (epoch) alınmıştır. Yapay sinir ağları ile çoklu regresyon modelinin iyi uyumunun karşılaştırılmasında düzeltilmiş belirleme katsayısı (R2) , hata kareler ortalamasının karekökü (Root Mean Square Error-RMSE), ortalama mutlak sapma (Mean Absolute Deviation-MAD) ve ortalama mutlak yüzde hata (Mean Absolute Percentage Error-MAPE) performans kriterleri kullanılmıştır. Analizler sonucunda yapay sinir ağları modeli ile ilk beş laktasyona ait R2 değerleri 0.62-0.85 arasında, RMSE değerleri 480.9-1682.8 arasında, MAD değerleri 325.2-1381.7 ve MAPE değerleri 6.1-20.2 arasında değişim göstermiştir. Çoklu doğrusal regresyonda ise bu değerler sırası ile R2 için 0.30 ile 0.75 arasında, RMSE için 1964.8-3008.7 arasında, MAD değeri 1576.6-2458.3 arasında ve MAPE değeri 24.7-35.6 arasında bulunmuştur. Söz konusu kriterlere göre bu modeller karşılaştırıldığında, bu çalışmada kullanılan süt verimlerinin tahminlenmesinde yapay sinir ağı modelinin çoklu doğrusal regresyon modelinden daha iyi uyum sağladığı gözlenmiştir. Dolayısıyla, yapay sinir ağlarının regresyon analizine alternatif bir metod olabileceği sonucuna ulaşılmıştır.
Tam Kayıt
| Alan | Değer | Dil |
|---|---|---|
| creativeworkseries.issn | 1300-6045 | |
| dc.date.accessioned | 2026-10-22T10:19:24.116460347Z | |
| dc.date.available | 2026-10-22T10:19:24.116460347Z | |
| dc.identifier.uri | https://rdlopen.rawdatalibrary.net/r/gumushane/11820 | |
| dc.publisher | Veteriner Fakultesi Dergisi | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.title | Kafkas Universitesi Veteriner Fakultesi Dergisi | |
| dspace.entity.type | Journal |