Sürdürülebilir Kalkınma Amaçları

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• Derleme MakaleAçık Erişim2025/r/gumushane/10413
  Synergistic Effects of Exercise and Nano-Curcumin Supplementation in Women with Lifestyle-Related Diseases: A Scoping Review

  Cherappurath, Nafih; Navaf, Muhammed; Ceylan, Halil Ibrahim; Elayaraja, Masilamani; Sunooj, Kappat Valiyapeediyekkal; Satheesan, Saranya T.; Thoompenthodi, Muhammed Ali; Perumbalath, Shamshadali; Bayrakdaroglu, Serdar; Muntean, Raul Ioan

  Background/Objectives: Lifestyle-related diseases such as obesity, diabetes, hypertension, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and osteoarthritis disproportionately affect women due to hormonal, metabolic, and socio-cultural factors. Emerging evidence suggests that combining structured exercise with nano-curcumin, a bioavailable phytochemical formulation with potent antioxidant and anti-inflammatory properties, may provide synergistic benefits. This scoping review systematically synthesizes available evidence on the combined effects of nano-curcumin supplementation and exercise interventions on health outcomes in women with lifestyle-related diseases. Methods: Following the Joanna Briggs Institute methodology and the PRISMA-ScR framework, a comprehensive database search was conducted in March 2025 and updated in June 2025. Records were retrieved from Scopus (n = 30), Web of Science (n = 22), PubMed (n = 18), and other sources (n = 71), yielding a total of 141 studies. After screening and deduplication, eight studies met the inclusion criteria and were included in this review. All the studies were conducted in Iran with small sample sizes (12-53 participants) and short intervention durations (6-16 weeks). Therefore, the current evidence is geographically and demographically limited. Results: Across the included trials, the combined interventions produced additive or synergistic improvements in oxidative stress markers, inflammatory cytokines, lipid and glucose metabolism, cardiovascular function, pulmonary capacity, muscle fitness, and psychological outcomes (e.g., depression). When paired with nano-curcumin supplementation at different concentrations, high-intensity interval training, aerobic exercise, Pilates, and resistance training consistently outperformed exercise or supplementation alone in modulating antioxidant defenses, reducing systemic inflammation, and improving metabolic risk factors. Conclusions: The integration of exercise and nano-curcumin supplementation appears to confer superior benefits for women with lifestyle-related diseases compared with either approach alone. These findings highlight the potential of combining phytochemicals with lifestyle interventions to optimize women's health outcomes. However, most available evidence originates from small, short-term studies in single geographic regions. Large-scale, multicenter, randomized controlled trials with diverse populations are warranted to establish standardized protocols and optimal dosing strategies, and to assess long-term safety and efficacy.

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• MakaleAçık Erişim2025/r/gumushane/13550
  Casein Supplementation Timing and Exercise Performance in Soccer Players: Pre-Sleep vs. Post-Exercise Intake—A Randomized Controlled Trial

  Bayrakdaroğlu, Serdar; Ateş, Zeynep Hazal; Ceylan, Halil İbrahim; Kul, Murat; Muntean, Raul Ioan; Dhahbi, Wissem

  Background: Nutrient timing strategies may influence recovery and performance in athletes; however, the effects of ingesting casein protein before sleep versus immediately after exercise remain unclear. This study compared the acute effects of pre-sleep and post-exercise ingestion of casein on high-intensity anaerobic performance in highly trained soccer players. Methods: Twenty-four highly trained male soccer players (mean age: 20.6 ± 1.8 years) were randomly assigned to three groups: post-exercise casein ingestion group (PECIG; n = 8), pre-sleep casein ingestion group (PSCIG; n = 8), and control group (CG; n = 8). Following a standardized high-intensity resistance training protocol, participants consumed 30 g of micellar casein dissolved in 300 mL of water either immediately after exercise or 30–60 min before bedtime. Performance was assessed using the Countermovement Jump (CMJ), the Illinois Agility Test (IAT), and the Running-based Anaerobic Sprint Test (RAST), which were conducted both before and 24 h after the training session. Results: Repeated-measures ANOVA revealed significant group-by-time effects for CMJ (F = 8.21, p = 0.002, η2p = 0.36) and RAST performance variables, including peak power (F = 6.94, p = 0.003, η2p = 0.32), mean power (F = 7.42, p = 0.002, η2p = 0.34), and fatigue index (F = 5.87, p = 0.008, η2p = 0.28). Post hoc analyses showed that PSCIG significantly improved CMJ (Δ = +1.45 cm; p < 0.001, d = 2.04) and RAST mean power (Δ = +125.14 W; p = 0.002, d = 1.55) compared with the control condition. PECIG significantly enhanced RAST peak power (Δ = +205.79 W; p = 0.001, d = 1.64), mean power (Δ = +128.43 W; p = 0.013, d = 1.24), and fatigue index (Δ = +4.12 W/s; p = 0.010, d = 1.29) relative to CG. No performance differences were observed between PSCIG and PECIG timing conditions (all p > 0.05). Conclusions: Both pre-sleep and post-exercise casein ingestion enhanced anaerobic performance in highly trained soccer players, with each timing method favoring different performance outcomes. However, neither strategy demonstrated superiority over the other, suggesting that casein timing may be flexibly applied according to athletes’ preferences and training contexts.

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• Derleme MakaleAçık Erişim2024/r/gumushane/14271
  Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions

  Ağagündüz, Duygu; Yeşildemir, Özge; Koçyiğit, Emine; Koçak, Tevfik; Özen Ünaldı, Buket; Ayakdaş, Gamze; Budán, Ferenc

  Oxylipins are oxidized fatty acids, both saturated and unsaturated, formed through pathways that involve singlet oxygen or dioxygen-mediated oxygenation reactions and are primarily produced by enzyme families such as cyclooxygenases, lipoxygenases, and cytochrome P450. These lipid-based complex bioactive molecules are pivotal signal mediators, acting in a hormone-like manner in the pathophysiology of numerous diseases, especially cardiometabolic diseases via modulating plenty of mechanisms. It has been reported that omega-6 and omega-3 oxylipins are important novel biomarkers of cardiometabolic diseases. Moreover, collected literature has noted that diet and dietary components, especially fatty acids, can modulate these oxygenated lipid products since they are mainly derived from dietary omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) or linoleic acid and α-linolenic by elongation and desaturation pathways. This comprehensive review aims to examine their correlations to cardiometabolic diseases and how diets modulate oxylipins. Also, some aspects of developing new biomarkers and therapeutical utilization are detailed in this review.

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• Derleme MakaleYayıncıda açık erişim2024/r/gumushane/14102
  From Garden to Pillow: Understanding the Relationship between Plant-Based Nutrition and Quality of Sleep

  Arslan, Neslihan; Bozkır, Eda; Koçak, Tevfik; Akin, Meleksen; Yilmaz, Birsen

  The effect of diet on sleep quality has been addressed in many studies; however, whether/how plant-based diets (PBDs) impact sleep-related parameters has not been explored in detail. This review aims to give an overview of the components of PBDs and the possible mechanisms through which PBDs may improve sleep quality. Studies have indicated that diets such as PBDs, which are typically high in fruits, vegetables, nuts, seeds, whole grains, and fiber, are associated with better sleep outcomes, including less fragmented sleep and improved sleep duration. Several mechanisms may explain how PBDs impact and/or improve sleep outcomes. Firstly, PBDs are characteristically rich in certain nutrients, such as magnesium and vitamin B6, which have been associated with improved sleep patterns. Secondly, PBDs are often lower in saturated fats and higher in fiber, which may contribute to better overall health, including sleep quality. Additionally, plant bioactive compounds like phytochemicals and antioxidants in fruits, vegetables, and herbs may have sleep-promoting effects. According to available data, PBD and Mediterranean diet elements promise to enhance sleep quality; however, it is crucial to note that diets should be customized based on each person’s needs.

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