Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2024/r/gumushane/13937
  Characterization of biodegradable bi-layer films from thermoplastic starch and poly-l-lactic acid

  Parlak, Mahmut Ekrem; Uzuner, Kubra; Ozdemir, Sebahat; Kirac Demirel, Fatma Tuba; Dundar, Ayse Neslihan; Sahin, Oya Irmak; Dagdelen, Adnan Fatih; Odabas, Halil Ibrahim; Saricaoglu, Furkan Turker

  This study aimed to enhance the oxygen barrier properties of polylactic acid (PLA) film, a biodegradable packaging material with high oxygen permeability (OP). Bi-layer films were produced by coating thermoplastic starch (TPS) onto PLA films in various ratios while maintaining constant film thickness. The mechanical, optical, barrier, thermal, hydrophobicity, moisture sorption, and microstructural properties of the films were analyzed. Increasing the TPS ratio elevated moisture content (MC), water uptake, solubility, and opacity while enhancing UV barrier properties. TPS coating reduced tensile and burst strength but increased the burst deformation of the bi-layer films. Bi-layer film production resulted in a water vapor permeability increase of 59.26%–94.44% compared with neat PLA while decreasing OP by 2.52%–29.66%. The equilibrium moisture content (EMC) rose with higher TPS ratios, displaying type II isotherms. FTIR analysis indicated no chemical interactions between PLA and TPS. Increasing the TPS ratio decreased PLA crystallinity, supporting the mechanical and barrier properties of the bi-layer films. Neat and bi-layer films exhibited smooth, homogeneous surfaces, with a visible interface in the cross-section of the bi-layer films. In conclusion, TPS shows promise as an alternative to improve oxygen barrier properties in PLA films without adversely affecting other properties.

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• MakaleAçık Erişim2014/r/gumushane/10393
  Poly(ε-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing β-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications

  Sezer, Umran Aydemir; Arslantunali, Damla; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin

  In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos-2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110.

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