Sürdürülebilir Kalkınma Amaçları

• 1
• 1
• 1

• MakaleAçık Erişim2026/r/gumushane/12190
  Process Intensification Sonocatalytic Degradation of Malachite Green Wastewater over Hydrothermally Engineered M-ZLT@Co3O4 Nanocatalyst: Structure–Activity Relationships, Radical-Mediated Mechanism and Degradation Pathways

  Kıranşan, Murat

  This study reports the sonocatalytic degradation of malachite green (MG) in media using synthesized Co3O4 nanoparticles and a CTAB-modified zeolite supported Co3O4 hybrid nanocatalyst (M-ZLT@Co3O4). The catalysts were characterized by XRD, FT-IR, SEM-EDX, TEM, XRF, N2 adsorption–desorption, BET, and BJH analyses, verifying crystalline Co3O4 formation, successful immobilization on the modified zeolite support, porous architecture, morphology and elemental distribution. Under optimized conditions of 1 g L−1 catalyst dosage, 20 mg L−1 MG concentration, natural pH, and 300 W L−1 ultrasonic power, M-ZLT@Co3O4 achieved 99.31% ± 0.45% degradation within 120 min. Decreasing the MG concentration to 5 mg L−1 increased the efficiency to 99.96% ± 0.64%, confirming high activity at low pollutant loading. The degradation followed pseudo-first-order kinetics, with kapp values of 0.0042–0.0595 min−1 depending on catalyst dosage, 0.0046–0.0667 min−1 for initial MG concentration, and 0.0117–0.0620 min−1 under pH conditions. Water matrix inhibition followed distilled water (99.31%) > tap water (96.08%) > river water (88.84%) > lake water (86.90%), whereas higher ultrasonic power increased degradation from 91.98% at 200 W L−1 to 99.90% at 500 W L−1. Dye degradation followed MG (99.31%) > CR (95.78%) > BY2 (92.15%) > MV (90.24%) > AO7 (85.62%) > RB19 (82.49%). Comparative tests demonstrated performance for US/M-ZLT@Co3O4 (99.31%) compared with US/Co3O4 nanoparticles (78.48%), US/ZLT (72.86%), and US/MG alone (35.71%). The best activity was obtained at 0.8–2 g L−1 catalyst dosage and 5–20 mg L−1 MG concentration, while reusability tests showed a decrease from 99.31% to 78.82% after six cycles, indicating promising stability.

  • 
  • 
  İncele
• Derleme MakaleAçık Erişim2025/r/gumushane/10235
  Therapeutic Bioactivity Exerted by the Apis mellifera Bee Venom and Its Major Protein Melittin: A Scoping Review

  Erdogan, Perihan Mutlu; Bilgili-Tetikoglu, Funda; Çelik-Uzuner, Selcen; Yildiz, Oktay; Kolayli, Sevgi; Mossialos, Dimitris

  Honey bee (Apis mellifera) products have been extensively utilized in traditional medicine. Bee venom (BV) is one of the major bee products with a high concentration of the small peptide melittin (MEL) and exerts bioactivity ranging from anti-microbial to anti-inflammatory and anti-cancer. This scoping review aims to sum up research articles on the bioactivity exerted by BV and MEL published in PubMed and Scopus from 2010 onwards. PRISMA guidelines were implemented to analyze the relevant literature; we ended up with 425 research articles. Bioactivity of BV and MEL was grouped as (i) anti-inflammatory (85), (ii) immunomodulatory (37), (iii) anti-microbial (179), (iv) anti-cancer (170), and (v) anti-oxidant (32). Although there is a significant body of research on the anti-cancer and anti-microbial activity of BV and MEL, their anti-oxidant, anti-inflammatory and immunomodulatory properties have received comparatively less attention. Many studies on the immunomodulatory effects of BV or MEL have focused on cancer. However, the effects on Parkinson's and Alzheimer's disease have not been extensively studied regarding the anti-inflammatory effects. Given the critical role of the immune system and inflammatory response in cancer, neurodegenerative diseases, senescence and against infections, it is paramount to further explore the immunomodulatory and anti-inflammatory potential of BV and MEL.

  • 
  İncele
• MakaleAçık Erişim2023/r/gumushane/12007
  Phenolic Constituents, Antioxidant and Antimicrobial Activity and Clustering Analysis of Propolis Samples Based on PCA from Different Regions of Anatolia

  Altuntaş, Ümit; Güzel, İsmail; Özçelik, Beraat

  This study aimed to evaluate the biochemical composition and biological activity of propolis samples from different regions of Türkiye to characterize and classify 24 Anatolian propolis samples according to their geographical origin. Chemometric techniques, namely, principal component analysis (PCA) and a hierarchical clustering algorithm (HCA), were applied for the first time to all data, including antioxidant capacity, individual phenolic constituents, and the antimicrobial activity of propolis to reveal the possible clustering of Anatolian propolis samples according to their geographical origin. As a result, the total phenolic content (TPC) of the propolis samples varied from 16.73 to 125.83 mg gallic acid equivalent per gram (GAE/g) sample, while the number of total flavonoids varied from 57.98 to 327.38 mg quercetin equivalent per gram (QE/g) sample. The identified constituents of propolis were phenolic/aromatic acids (chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, and trans-cinnamic acid), phenolic aldehyde (vanillin), and flavonoids (pinocembrin, kaempferol, pinobanksin, and apigenin). This study has shown that the application of the PCA chemometric method to the biochemical composition and biological activity of propolis allows for the successful clustering of Anatolian propolis samples from different regions of Türkiye, except for samples from the Black Sea region.

  İncele
• MakaleAçık Erişim2021/r/gumushane/10591
  LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kinkor (Ferulago stellata)

  Kiziltas, Hatice; Bingol, Zeynebe; Gören, Ahmet Ceyhan; Kose, Leyla Polat; Durmaz, Lokman; Topal, Fevzi; Alwasel, Saleh H.; Gulcin, Ilhami

  Kinkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kinkor (Ferulago stellata), some putative antioxidant methods such as DPPHGreek ano teleia scavenging activity, ABTS(center dot+) scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and alpha-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kinkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kinkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kinkor (Ferulago stellata) demonstrated IC50 values of 1.772 mu g/mL against acetylcholinesterase (AChE), 33.56 +/- 2.96 mu g/mL against alpha-glycosidase, and 0.639 mu g/mL against alpha-amylase enzyme respectively.

  İncele