2026-10-23T17:48:17Zhttps://gumushane-rdlopen.rawdatalibrary.net/oai/requestoai:gumushane-rdlopen.rawdatalibrary.net:gumushane/164292026-10-22T11:41:01Zopenairecom_gumushane_10000col_gumushane_10001Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destructionÖzgur, A.Yemis, T.Basbulut, E.Turgut, N. F.Özdemir, D.Akgul, G.Mehel, D. M.Celebi, M.CholesteatomaBone DestructionChronic Otitis MediaBackground Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity. Method Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared. Results There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction. Conclusion This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.CAMBRIDGE UNIV PRESS2021-10Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/16429https://doi.org/10.1017/s00222151210021030022-2151enJOURNAL OF LARYNGOLOGY AND OTOLOGYinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/16429