2026-10-23T16:02:58Zhttps://gumushane-rdlopen.rawdatalibrary.net/oai/request

oai:gumushane-rdlopen.rawdatalibrary.net:gumushane/161152026-10-22T11:38:24Zopenairedrivercom_gumushane_10000col_gumushane_10001

Sequence Variant in the LPIN1 gene in Patients with Metabolic SyndromeKural, Birgul VanizorDeger, OrhanErem, CihangirYücesan, Fulya BalabanBarlak, YasamTuran, IbrahimAliyazicioglu, Rezzanmetabolic syndromeLPIN1lipin-1Objective: Metabolic syndrome (MetS) is a complex disease characterized by insulin resistance, abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia and low HDL-cholesterol level. The aim of the study was to evaluate the sequence variations in the LPIN1 gene in MetS. This gene codes lipin-1 protein which functions as Mg-dependent phosphatidic phosphatase enzyme and transcriptional coactivator. Material and Methods: The study groups included 73 MetS (19 M/54 F) and 56 non-MetS (16 M/40 F). Sequence variation in exons 2, 4, 5 and 14 of the LPIN1 gene were investigated by DNA sequencing method. Results: c.696 G>C variant (p.S232S) in exon 5 was observed in only one women with MetS. But this variation is not important because of coding same amino acid. Conclusion: Any important sequence variant was not detected in exons 2, 4, 5 and 14 in the LPIN1 gene in MetS.WALTER DE GRUYTER GMBH2013Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/16115https://doi.org/10.5505/tjb.2013.410330250-4685enTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/16115