2026-10-23T14:55:20Zhttps://gumushane-rdlopen.rawdatalibrary.net/oai/requestoai:gumushane-rdlopen.rawdatalibrary.net:gumushane/152112026-10-22T11:37:45Zopenairedrivercom_gumushane_10000col_gumushane_10001com_gumushane_10007col_gumushane_10180Effect of Turkish pollen and propolis extracts on caspase-3 activity in myeloid cancer cell linesUçar, MeltemDeğer, OrhanGerigelmez, Asuman YiğitCengiz, SevilBarlak, YaşamOvalı, ErcümentApoptosisCaspase-3Myeloid cancerPollenPropolisPurpose: To investigate the apoptosis-inducing capacity of dimethyl sulfoxide (DMSO) extracts of bee pollen and propolis in HL-60 Myeloid Cancer Cell Lines. Methods: DMSO extracts of pollen and propolis were incubated separately with HL-60 cells, and caspase-3 activity evaluated. In order to determine the cell cycle characteristics of HL-60 cells with and without extracts of pollen and propolis, the cells were analysed using flow cytometry. Results: The DMSO extract of propolis (0.5 mg/mL) increased apoptosis from undetectable levels to 60.1%, while maintaining cell viability. The DMSO extract of pollen (2 mg/ml) increased apoptosis from undetectable levels to 52.2% while decreasing cell viability by 62%. Caspase-3 activity in HL-60 cells incubated with DMSO extracts of pollen and propolis were 3.6-to 12-fold higher than in controls. Conclusion: Turkish pollen and propolis individually increase apoptosis and the activity of caspase-3 in HL-60 cells. This finding indicates that bee products may have beneficial effects in the treatment of cancer.University of Benin2016Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/15211https://doi.org/10.4314/tjpr.v15i11.201596-5996enTropical Journal of Pharmaceutical Researchinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/15211