2026-10-23T16:03:12Zhttps://gumushane-rdlopen.rawdatalibrary.net/oai/request

oai:gumushane-rdlopen.rawdatalibrary.net:gumushane/150272026-10-22T11:37:35Zopenairedrivercom_gumushane_10000col_gumushane_10001com_gumushane_10010col_gumushane_10182

The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymesTopal, Meryemacetylcholinesteraseenzyme inhibitionnatural productsesamolα-glycosidaseSesamol (1,3-benzodioxol-5-ol) is found in the oilseed product, sesame. In our study, the inhibitory effects of sesamol compound on acetylcholinesterase and α-glycosidase enzymes were evaluated. Another aim of this study was to compare the inhibitory effects of sesamol to acarbose for α-glycosidase enzyme and tacrine for acetylcholinesterase (AChE). Sesamol exhibited non-competitive inhibition for both metabolic enzymes. IC50 values for AChE and α-glycosidase enzymes were calculated as 86.63 nM and 99.00 nM, respectively. On the other hand, Ki values were calculated as 46.68 nM and 75.33 nM for AChE and α-glycosidase enzymes, respectively. According to the obtained results showed effective inhibition at low concentrations.Taylor and Francis Inc.2019Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/15027https://doi.org/10.1080/10942912.2019.16562341094-2912enInternational Journal of Food Propertiesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/15027