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Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing β-lactamases in Pseudomonas aeruginosa in TurkeyIraz, MeryemDuzgun, Azer OzadCicek, Aysegul CopurBonnin, Remy A.Ceylan, AysenurSaral, AysegulNordmann, PatriceSandalli, CemalPseudomonas aeruginosaCarbapenemasebeta-lactamaseESBLClass 1 integronPseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), extensively-drug resistant (n = 5), or pan-drug resistant (n = I). PCR and DNA sequence analysis revealed that 1 strain possessed the bla(GES-5) and another carried a novel bla(VIM) variant, named VIM-38. This new gene exhibited 1 amino acid substitution (Ala265Val) in comparison to its closest variant, VIM-5. Both VIM encoding genes were clones and demonstrated similar susceptibility profile when expressed in identical background. The presence of VIM-38 increases the diversity of carbapenemases in Turkey. (C) 2014 Elsevier Inc. All rights reserved.ELSEVIER SCIENCE INC2014-03Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/10597https://doi.org/10.1016/j.diagmicrobio.2013.12.0030732-8893enDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASEinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/10597