2026-10-23T14:57:07Zhttps://gumushane-rdlopen.rawdatalibrary.net/oai/request

oai:gumushane-rdlopen.rawdatalibrary.net:gumushane/104282026-10-22T11:07:34Zopenairecom_gumushane_10000col_gumushane_10001com_gumushane_10007col_gumushane_10171

Carbonic anhydrase I and II autoantibodies in Behcet's diseaseMentese, A.Alver, A.Demir, S.Sumer, A.Yaman S, OzerKarkucak, M.Capkin A, AydinUs, Altay D.Turan, IAutoantibodyBehcet's diseaseCarbonic anhydraseBackground: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BDPUBLISAUDE-EDICOES MEDICAS LDA2017-01Articlehttps://rdlopen.rawdatalibrary.net/r/gumushane/104280303-464XenACTA REUMATOLOGICA PORTUGUESAinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://gumushane-rdlopen.rawdatalibrary.net/tr/items/gumushane/10428